Targeting Residual Inflammatory Risk: A Shifting Paradigm for Atherosclerotic Disease
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چکیده
منابع مشابه
Shifting the Disease Management Paradigm From Glucose
W ith the worldwide growing prevalence of obesity and type 2 diabetes, cardiovascular disease (CVD), diabetic nephropathy, retinopathy, and neuropathy as principal complications of diabetes are expected to become a major public health challenge. Diabetes accounts for at least double the number of death rates compared with otherwise healthy individuals. Hyperglycemia represents the hallmark of d...
متن کاملShifting the Disease Management Paradigm From Glucose
V ascular comorbidities and complications are the major causes of excessive mortality and costs in patients with diabetes (1,2). For more than half a century, overwhelming evidence has been accumulating that demonstrates significant harmful effects of hyperglycemia. As shown in the Multiple Risk Factor Intervention Trial (MRFIT) study, at any given level of major cardiovascular risk factors, di...
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n engl j med 363;8 nejm.org august 19, 2010 781 Attia P, Phan GQ, Maker AV, et al. Autoimmunity correlates 4. with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005;23:6043-53. Schwartzentruber DJ, Lawson D, Richards J, et al. A phase III 5. multi-institutional randomized study of immunization with the gp100:209-217(210M)...
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Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in ...
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Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerotic vascular disease. Intracellular redox status is tightly regulated by oxidant and antioxidant syst...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2019
ISSN: 2297-055X
DOI: 10.3389/fcvm.2019.00016